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本文对一例肝癌病人的淋巴细胞进行了初步的观察,发现其小淋巴细胞仅占淋巴细胞总数的29％,淋巴细胞胞浆中微核出现率为19‰.淋巴细胞染色体2n≠46者占80％,且其中大多数为亚二倍体(占所观察细胞的78％)。并选择染色体众数的中期相细胞进行了核型分析。我们认为大、中、小型淋巴细胞比例失调;微核的出现与细胞的非整体化等均与恶性病变相关联。至于它们与肝癌的关系,我们将根据较多的病例继续进行观察。
In this paper, a preliminary observation of the lymphocytes of a patient with liver cancer revealed that its small lymphocytes accounted for only 29% of the total number of lymphocytes, and the frequency of micronuclei in the cytoplasm of lymphocytes was 19%. The number of lymphocyte chromosomes 2n≠46 accounted for 80 %, and most of them are hypodiploids (78% of the observed cells). The karyotype analysis was performed by selecting the metaphase population of chromosomes. We believe that the proportion of large, medium and small lymphocytes is imbalanced; the appearance of micronuclei and the non-integralization of cells are all associated with malignant lesions. As for their relationship with liver cancer, we will continue to observe according to more cases.