目的　调查D18S872基因座在成都汉族 ,新疆维族和蒙古族 ,甘肃回族 4个民族中的遗传多态性 ,获得群体遗传学基本数据。　方法　等位基因分型标准物制备采用分子克隆技术 ,样本基因分型采用PCR和PAG垂直电泳技术、银染显色方法。　结果　获得D18S872基因座等位基因分型标准物及该基因座在 4个群体中的遗传学数据。　结论　结果表明D18S872基因座在法医学个人识别和亲子鉴定中有一定的应用价值。 Objective To investigate the genetic polymorphism of D18S872 locus in four ethnic groups in Chengdu Han, Xinjiang Uygur and Mongolian, and Gansu Hui nationality and obtain the basic data of population genetics. Methods The allelic typing standard was prepared by molecular cloning. The genotypes of the samples were analyzed by PCR, PAG vertical electrophoresis and silver staining. Results The allelic genotypes of D18S872 locus and the genetic data of the locus in four populations were obtained. Conclusion The results indicate that the D18S872 locus has a certain value in personal identification and paternity testing of forensic medicine.