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目的:比较激素反添加疗法与醋酸曲普瑞林用于治疗子宫内膜异位症患者的疗效。方法:选取2013年11月—2015年11月间诊治的子宫内膜异位症患者70例,根据随机数字法将患者分为观察组和对照组,每组35例,对照组患者均给予醋酸曲普瑞林治疗,观察组患者在对照组治疗的基础上均给予激素反添加疗法(戊酸雌二醇与替勃龙)治疗,比较两组患者治疗后的血清E_2(雌二醇)、FSH(卵泡刺激素)、LH(黄体生成素)值以及囊肿直径、血清CA125和MMP-1(基质金属蛋白酶)值的变化情况。结果:治疗前两组患者的E_2、FSH、LH值经比较其差异无统计学意义(P>0.05);治疗后观察组患者的血清E_2值明显高于对照组(P<0.05),治疗后两组患者的FSH、LH值经比较其差异无统计学意义(P>0.05);治疗前两组患者的囊肿直径、血清CA125和MMP-1值经比较其差异无统计学意义(P>0.05);治疗后观察组患者的囊肿直径、血清CA125值明显高于对照组(P<0.05),血清MMP-1值明显低于对照组(P<0.05)。结论:采用激素反添加疗法治疗子宫内膜异位症患者的疗效优于醋酸曲普瑞林的疗效。
OBJECTIVE: To compare the efficacy of antiretroviral therapy with triptorelin acetate in the treatment of patients with endometriosis. Methods: Seventy patients with endometriosis diagnosed and treated between Nov. 2013 and Nov. 2015 were enrolled. According to the random number method, the patients were divided into the observation group and the control group, with 35 cases in each group. The patients in the control group were given acetic acid Triptorelin treatment, the observation group patients were given the hormone anti-add therapy (estradiol valerate and tibolone) on the basis of the treatment of the control group, the serum E_2 (estradiol) after treatment in both groups were compared, FSH (follicle stimulating hormone), LH (luteinizing hormone) values, as well as cyst diameter, serum CA125 and MMP-1 (matrix metalloproteinase) values. Results: The E_2, FSH and LH values of the two groups before treatment had no significant difference (P> 0.05). After treatment, the serum E2 values of the observation group were significantly higher than those of the control group (P <0.05) There was no significant difference in FSH and LH between the two groups (P> 0.05). There was no significant difference in cyst diameter, serum CA125 and MMP-1 between the two groups before treatment (P> 0.05 ). After treatment, the cyst diameter, the serum CA125 level in the observation group were significantly higher than those in the control group (P <0.05), and the serum MMP-1 levels were significantly lower than those in the control group (P <0.05). CONCLUSIONS: Hormone anti-addition therapy is superior to triptorelin acetate in the treatment of patients with endometriosis.