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目的为研究三聚氰胺对孕鼠的毒性作用建立动物模型。方法以120、240、360、480、600、720 mg/kg.d剂量的三聚氰胺给孕鼠灌胃,对照组等量蒸馏水灌胃,观察孕鼠的生长及生产情况,采用ELISA检测新生鼠血液和肾脏中的三聚氰胺、检测新生鼠肾脏功能、HE染色观察新生鼠肾组织病理变化。结果灌胃剂量为720 mg/kg.d的实验组出现明显变化:孕鼠体重增长率降低(P<0.05);新生鼠产量降低(P<0.05);新生鼠血液和肾脏内三聚氰胺浓度高于对照组(P<0.05);新生鼠肾脏功能下降;肾脏组织出现明显病理变化。结论灌胃720 mg/kg.d浓度的三聚氰胺对孕鼠产生严重的毒性作用,成功建立了三聚氰胺对孕鼠毒性作用的动物模型。
Objective To study the toxic effect of melamine on pregnant rats to establish an animal model. Methods The pregnant rats were administered intragastrically with 120, 240, 360, 480, 600 and 720 mg / kg.d doses of melamine, while the control group was given distilled water. The growth and production of pregnant mice were observed. And melamine in kidneys, kidney function of neonatal rats was detected, and pathological changes of nephridial kidneys were observed by HE staining. Results The experimental group with a dose of 720 mg / kg.d had obvious changes: the weight growth rate of pregnant rats decreased (P <0.05), the production of neonatal rats decreased (P <0.05); the concentration of melamine in blood and kidneys of neonatal rats was higher than The control group (P <0.05); neonatal rat kidney function decreased; kidney tissue showed significant pathological changes. Conclusions The intragastric administration of melamine at a concentration of 720 mg / kg.d has a serious toxic effect on pregnant rats, and an animal model of the toxic effects of melamine on pregnant rats has been successfully established.