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目的探讨分析沙利度胺治疗克罗恩病的临床疗效。方法 40例克罗恩病患者,按照治疗方法的不同将其分为治疗组及对照组,各20例。对照组给予柳氮磺胺吡啶治疗,治疗组给予沙利度胺治疗。比较两组患者的治疗效果以及不良反应发生率。结果治疗组治疗总有效率为95.0%,高于对照组的70.0%,差异具有统计学意义(P<0.05)。治疗组不良反应发生率为5.0%(1/20),低于对照组的30.0%(6/20),差异具有统计学意义(P<0.05)。结论沙利度胺治疗克罗恩病具有显著的临床疗效,不良反应较少,有利于患者的康复,值得临床推广应用。
Objective To investigate the clinical efficacy of thalidomide in the treatment of Crohn’s disease. Methods Forty patients with Crohn ’s disease were divided into treatment group and control group according to the different treatment methods, 20 cases in each. The control group was given sulfasalazine, and the treatment group was given thalidomide. The treatment effect and incidence of adverse reactions in both groups were compared. Results The total effective rate of the treatment group was 95.0%, which was higher than that of the control group (70.0%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was 5.0% (1/20), which was lower than that in the control group (30.0%, 6/20). The difference was statistically significant (P <0.05). Conclusion Thalidomide treatment of Crohn’s disease has significant clinical efficacy, fewer adverse reactions, is conducive to the rehabilitation of patients, it is worth clinical promotion and application.