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目的研究电流、电压和供应室溶液的pH值对盐酸环丙沙星离子导入渗透速率的影响。方法以盐酸环丙沙星为模型药物,采用Valia-chien双室扩散池,分别测定不同电流强度、不同电压强度及不同pH溶液的离子导入渗透速率和增渗倍数。结果盐酸环丙沙星离子导入渗透速率和增渗倍数随着电流强度的增加而增加;当电流强度恒定,盐酸环丙沙星的离子导入增渗倍数随着电压强度的增加而增加;供应室溶液的pH值对离子导入透皮渗透有影响,当pH 3.5时,促渗效果较好。结论电学因素及供应室溶液的pH值是影响盐酸环丙沙星离子导入渗透速率的重要因素。
Objective To study the influence of current, voltage and solution pH on the iontophoresis rate of ciprofloxacin hydrochloride. Methods Ciprofloxacin hydrochloride was used as a model drug. Valia-chien double chamber diffusion cells were used to determine the iontophoresis rate and permeation times of different current strengths, different voltage intensities and different pH solutions. Results The iontophoresis and permeation rate of ciprofloxacin hydrochloride increased with the increase of the current intensity. When the current intensity was constant, the ion-permeation multiplication factor of ciprofloxacin hydrochloride increased with the increase of the voltage intensity. The supply chamber The pH value of the solution has an effect on the transdermal permeation of the iontophoresis. When the pH value is 3.5, the permeation enhancement effect is better. Conclusion The electrical factors and the pH value of the solution in the chamber are important factors affecting the infiltration rate of ciprofloxacin hydrochloride.