泰必利(tiapridum)是一种新型神经精神安定药。化学学名为N-(2-二乙胺乙基)-2-甲氧基-5-甲烷磺酰基苯甲酰胺。药用是其盐酸盐(由江苏淮阴制药厂生产)。适应症有运动失常如抽动秽语综合征;反应性行为障碍伴有攻击行为和精神运动不稳定,痛性痉挛,各种疼痛综合征和顽固性头痛;酒精所致的障碍等。1980年我系试制成功。本实验研究了泰必利的含量测定方法。泰必利原料含量采用高氯酸非水溶液滴定法测定,甲紫为指示剂,滴定溶液由紫变蓝色即为终点。测定了9个批号的试制品,含量均在99%以上,CV%为0.17%。泰必利原料若采用紫外分光光度测定,泰必利95%乙醇溶液和水溶液在212、235和287±1nm均有吸收峰,235±1nm水溶液为肩峰,287nm可作为定量测定泰必利的波长,水溶液吸收系数(E ?)为65。它的水 Tiapridum is a new neuroleptic drug. The chemical name is N- (2-diethylaminoethyl) -2-methoxy-5-methanesulfonylbenzamide. Medicinal hydrochloride is its (from Huaiyin Pharmaceutical Factory production). Indications such as motor disorders such as Tourette’s syndrome; Reactive behavioral disorders associated with aggressive and psychomotor instability, cramps, various pain syndromes and refractory headaches; alcohol-induced disorders. In 1980 I successfully trial system. The experimental study of tiapride content determination method. Tropicilli raw material content of perchloric acid non-aqueous solution titration method, methyl violet indicator, titration solution from purple to blue is the end point. Nine batches of the trial products were determined, the content of more than 99%, CV% was 0.17%. Tropicine raw materials using UV spectrophotometry, Tropicine 95% ethanol solution and aqueous solution of 212,235 and 287 ± 1nm absorption peak, 235 ± 1nm aqueous solution for the shoulder, 287nm can be used as a quantitative determination of tiapride Wavelength, aqueous absorption coefficient (E?) Of 65. It’s water