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3例男性患者均因结婚多年不育就诊.体检无特殊发现,男性特征明显,身高智力正常.多次精液检查中,2例无精子,诊断为无精症;1例精子形态异常者较多,呈现双头、大头或小头,活动力差,其妻死胎2次.染色体检查时,G带各计数50个核型,分析5-10个核型,均为:46,XY(小Y).小Y的标准:Y染色体小于G组染色体,G显带无异常. 讨论:有关Y染色体长度的变化,早在50年代即有报道,但一直被视为正常多态性,存在于正常男性,无临床意义.近年来的研究表明,Y染色体变长(大Y)或变短(小Y),
3 cases of male patients were married for many years of infertility treatment .No special physical examination found that men have obvious characteristics, height and intelligence .Several semen examination, two cases of no sperm, diagnosis of azoospermia; 1 case of abnormal sperm morphology , Showing double head, head or head, poor activity, his wife stillbirth 2. Chromosome examination, G with a count of 50 karyotypes, analysis of 5-10 karyotypes are: 46, XY (small Y ) Y Y standard: Y chromosome smaller than G chromosome, G band without exception.Discussion: Y chromosome length changes, as early as the 50’s that have been reported, but has been regarded as normal polymorphism, exists in normal Men, no clinical significance in recent years, studies have shown that the Y chromosome longer (big Y) or shorter (small Y),