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本文报告了噻吗心安及双氢氯噻嗪单独与联合应用于原发性高血压治疗时,治疗效果与不良反应的比较。 61名病人随机分为三组。一组用噻吗心安,一组用双氢氯噻嗪,一组用噻吗心安+双氢氯噻嗪。经过12周治疗,三组病人的血压均显著下降,而以噻吗心安+双氢氯噻嗪组最为明显:平均由154/103mmHg下降至129/85mmHg。三组治疗有效率,噻吗心安+双氢氯噻嗪组为95.2%,噻吗心安组为80%,双氢氯噻嗪组为50%。不良反应,噻吗心安+双氢氯噻嗪组为33.3%,噻吗心安组为30%,双氢氯噻嗪组为43%。噻吗心安+双氢氯噻嗪组治疗的优点在于:(1)双氢氯噻嗪阻止了β-受体阻滞剂引起的体液蓄积。接受噻吗心安+双氢氯噻嗪及双氢氯噻嗪治疗的病人,体重均明显减少,而噻吗心安纽病人体重稍增加。(2)噻吗心安抑制了同双氢氯噻嗪有关的肾素活性的升高。
This article reports the efficacy and adverse effects of timolol and hydrochlorothiazide, both alone and in combination, in the treatment of essential hypertension. 61 patients were randomly divided into three groups. One group with timolol, a group with hydrochlorothiazide, a group with timolol + hydrochlorothiazide. After 12 weeks of treatment, the blood pressure was significantly decreased in all three groups, most notably in timolol + hydrochlorothiazide groups: from 154/103 mmHg to 129/85 mmHg on average. Three groups of treatment efficiency, timolol + hydrochlorothiazide group 95.2%, timolol group 80%, hydrochlorothiazide group 50%. Adverse reactions, timolol + hydrochlorothiazide 33.3%, timolol 30%, hydrochlorothiazide 43%. The advantages of timolol + hydrochlorothiazide therapy are: (1) Dihydrochlorothiazide prevents the accumulation of fluid by β-blockers. Patients receiving timolol + dihydrochlorothiazide and hydrochlorothiazide experienced significant reductions in body weight, with a slight increase in body weight in patients with timolol-newborn disease. (2) Timofusine inhibits the elevated renin activity associated with hydrochlorothiazide.