目的　探讨儿童急性淋巴细胞白血病 (ALL)髓系抗原表达与预后及其他临床特征的关系。方法　流式细胞仪直接免疫荧光法检测上海儿童医学中心 1999年 1月至 2 0 0 2年 12月收治的初诊 15 2例ALL患儿髓系抗原表达。结果　 15 2例患儿中髓系抗原表达阳性率 18 4 % ,髓系抗原表达与性别、年龄、外周血白细胞数、FAB分型、免疫分型、染色体改变等无关。髓系抗原表达阳性与阴性ALL患儿的完全缓解 (CR)率分别为 96 2 %、95 7%(P >0 0 5 ) ,复发率为 16 7%、19 6 % (P >0 0 5 )。结论　在ALL患儿中髓系抗原的表达不影响其预后 Objective To investigate the relationship between the expression of myeloid antigens in children with acute lymphoblastic leukemia (ALL) and their prognosis and other clinical features. Methods Flow cytometry direct immunofluorescence method was used to detect myeloid antigen expression in 152 cases of newly diagnosed ALL children admitted to Shanghai Children’s Medical Center from January 1999 to December 2002. Results The positive rate of myeloid antigen expression in 15 children was 18.4%. The myeloid antigen expression was not related to gender, age, peripheral leukocyte count, FAB typing, immunophenotyping and chromosomal changes. The complete remission (CR) rates of myeloid antigen positive and negative ALL children were 96 2% and 95 7% (P 0 05) respectively, with a relapse rate of 16 7% and 19 6% (P 0 05) ). Conclusions The expression of myeloid antigens in children with ALL does not affect their prognosis