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目的:探讨血清高教C-反应蛋白(hs-CRP)浓度与冠心病严重程度的关系。方法:纳入2004年7月～2005年7月收治的冠心病患者106例,其中男性59例,年龄32～80(59．4±13．22)岁;女性47例,年龄43～73 (57．8±9．46)岁。按WHO诊断标准进行分组,分为急性心肌梗死组、不稳定型心绞痛组、稳定型心绞痛组和正常对照组。同时纳入行冠状动脉照影的住院患者112例,其中男性67例,年龄38～81(60．26±9．82)岁;女性45例,年龄46～71(60．1±6．85)岁。根据造影结果进行血管损害程度积分,并据积分分组,分为0—2分组、3—7分组、8—12分组、>12分组。所有患者均空腹查hs-CRP,用统计学方法分析hs-CRP与冠状动脉斑块稳定性及冠状动脉狭窄程度及范围的定量关系。结果:急性心肌梗死组、不稳定型心绞痛组较稳定型心绞痛组及正常对照组血清hs—CRP脓度水平明显升高,冠状动脉血管损害程度积分高组较积分低组血清hs-CRP脓度水平明显升高,统计学差异均有显著性。结论:血清hs-CRP浓度水平可作为冠心病斑块稳定性及血管病变严重程度的一个重要预测指标。
Objective: To investigate the relationship between the serum high level of C-reactive protein (hs-CRP) and the severity of coronary heart disease. Methods: A total of 106 patients with coronary heart disease were enrolled from July 2004 to July 2005. Among them, 59 males were aged 32 to 80 years (59.4 ± 13.22 years) and 47 females (age, 43 to 73 years .8 ± 9.46) years old. According to WHO diagnostic criteria for grouping, divided into acute myocardial infarction group, unstable angina group, stable angina group and normal control group. 112 hospitalized patients undergoing coronary artery angiography were enrolled, including 67 males (aged 60-66 ± 9.82 years) and 45 females (aged 46-71) (60.1 ± 6.85 years) year old. Angiography results according to the degree of vascular damage integral, and according to the integral group, divided into 0-2 group, 3-7 group, 8-12 group,> 12 group. All patients were fasting hs-CRP, statistical analysis of hs-CRP and coronary plaque stability and coronary artery stenosis extent and extent of the quantitative relationship. Results: The serum levels of hs-CRP in acute myocardial infarction group and unstable angina group were significantly higher than those in stable angina group and normal control group. The levels of serum vascular endothelial growth factor (hs-CRP) Significantly increased levels of statistical differences were significant. Conclusion: The level of hs-CRP in serum can be used as an important predictor of plaque stability and the severity of vascular lesions.