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以流感病毒Ａ／ＦＭ１／１／４７（Ｈ１Ｎ１）鼠适应株，鼻腔内接种感染小鼠为模型，探讨了病毒感染过程中，自由基的产生以及在致病过程中的作用．结果表明，感染病毒的小鼠肺组织中氧自由基水平和黄嘌呤氧化酶活性显著升高，并与肺组织损伤和死亡率之间呈正相关．提示，氧自由基参与了病毒感染小鼠的致病过程，是造成组织损伤的重要因素．
The influenza A / FM1 / 1/47 (H1N1) murine adaptive strain and intranasally inoculated mice were used as models to investigate the generation of free radicals and their role in pathogenicity during virus infection. The results showed that the level of oxygen free radicals and xanthine oxidase activity in the lungs of mice infected with virus was significantly increased, which was positively correlated with lung injury and mortality. Tip, oxygen free radicals involved in the virus-infected mice pathogenic process, is an important factor in causing tissue damage.