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血栓闭塞性脉管炎的病因仍未明确,组织学证实所有病变血管各层均有单核细胞浸润,故认为可能与自身免疫有关。作者对患者进行了全身性和特异性细胞免疫及体液免疫学的研究,并对本病的免疫机制作了讨论,一般认为是由于营养缺乏和/或烟草过敏和/或感染等而诱发血管损伤,继而动脉抗原可能发生改变或暴露,而引起体液和细胞免疫反应,导致Ⅲ型和Ⅵ型的血管壁损伤,形成动脉炎,继发性血栓闭塞性脉管炎。现摘译如下。本文选择长期吸烟的40岁以下、出现下肢缺血的症状及体征和出现本病之组织学特征,包括以淋巴细胞浸润为主的远端血管全身性动脉炎、内皮细胞增生、有或无新生血管形成的血栓、无动脉硬化的患者10例为治疗组,并以排除血管疾患、年龄相近的正常人15例作对照。
The cause of thromboangiitis obliterans remains unclear. Histologically, mononuclear cells infiltrate in all layers of blood vessels in the lesion, suggesting that it may be related to autoimmunity. The authors conducted a systematic and specific study of cellular and humoral immunology in patients and discussed the immunological mechanisms of this disease, which are generally thought to induce vascular damage due to nutritional deficiencies and / or tobacco allergy and / or infection , And then the arterial antigens may be changed or exposed, causing humoral and cellular immune response, resulting in type â ... and â ... ¢ type of vascular wall injury, the formation of arteritis, secondary thromboangiitis obliterans. Now the translation is as follows. This article selects long-term smoking under the age of 40, the symptoms and signs of lower extremity ischemia and the histological features of the disease, including the main vascular infiltration of lymphocytes systemic arteritis, endothelial cell proliferation, with or without newborn Vascular thrombosis, non-arteriosclerosis in 10 patients for the treatment group, and to exclude vascular disease, 15 cases of normal age as a control.