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目的观察瑞舒伐他汀治疗老年慢性心力衰竭并房颤的临床效果。方法选取医院收治的慢性心力衰竭伴房颤患者54例,随机分为观察组和对照组,每组27例。对照组采用常规基础治疗,观察组在对照组基础上加用瑞舒伐他汀治疗,观察2组心功能分级与LVEF、房颤情况及血脂水平。结果 2组治疗后心功能均较治疗前改善,LVEF均较治疗前升高,且观察组高于对照组(P<0.05)。观察组房颤复发率和转为永久性房颤率低于对照组(P<0.05)。观察组治疗后总胆固醇、三酰甘油、低密度脂蛋白胆固醇低于治疗前和对照组,高密度脂蛋白胆固醇高于治疗前和对照组,差异均有统计学意义(P<0.05)。结论老年慢性心力衰竭伴发房颤患者在常规治疗基础上加用瑞舒伐他汀可以明显改善患者心功能,降低房颤复发率。
Objective To observe the clinical effect of rosuvastatin in the treatment of elderly patients with chronic heart failure and atrial fibrillation. Methods Totally 54 patients with chronic heart failure and atrial fibrillation admitted to hospital were randomly divided into observation group and control group with 27 cases in each group. The control group was treated with routine basic therapy. The observation group was treated with rosuvastatin on the basis of the control group. The heart function grading, LVEF, atrial fibrillation and blood lipid level were observed in the two groups. Results After treatment, the cardiac function in both groups improved compared with that before treatment. The LVEF in both groups was significantly higher than that before treatment, and the observation group was higher than the control group (P <0.05). The observation group atrial fibrillation recurrence rate and permanent AF was lower than the control group (P <0.05). After treatment, total cholesterol, triglyceride and low-density lipoprotein cholesterol in the observation group were lower than those before treatment and in the control group, and high-density lipoprotein cholesterol was higher in the observation group than before treatment and in the control group (P <0.05). Conclusion The elderly patients with chronic heart failure and atrial fibrillation combined with rosuvastatin on the basis of routine treatment can significantly improve cardiac function and reduce the recurrence rate of atrial fibrillation.