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目的探讨大动脉粥样硬化型脑梗死(acute cerebral infarction,ACI)患者的梗死面积及神经功能缺损程度与血清脂联素和高敏C-反应蛋白(high sensitivity C-reactive protein,hs-CRP)水平的关系。方法选取大动脉粥样硬化型脑梗死患者61例(ACI组)和健康体检者64例(对照组),并将ACI组按照患者梗死面积及神经功能缺损程度各分为三个亚组,分别检测其血清脂联素、hs-CRP水平,并进行比较。结果 ACI组治疗前血清脂联素水平明显低于对照组(P<0.05),hs-CRP水平明显高于对照组(P<0.05);小、中、大梗死亚组和轻、中、重脑卒中亚组的血清脂联素水平均依次增高,hs-CRP水平均依次降低,差异均有统计学意义(P<0.05);血清脂联素和hs-CRP水平呈负相关(r=-0.84,P<0.05)。结论大动脉粥样硬化型ACI患者的血清脂联素水平降低,而hs-CRP水平升高,两者呈负相关性;且两者的变化水平与脑梗死面积大小及神经功能缺损程度密切相关。
Objective To investigate the relationship between infarct size, neurological deficits and serum adiponectin and high sensitivity C-reactive protein (hs-CRP) levels in patients with acute cerebral infarction (ACI) relationship. Methods Sixty-one patients (ACI group) and 64 healthy subjects (control group) were enrolled in the study. The ACI group was divided into three subgroups according to the infarct size and neurological deficit. Their serum adiponectin, hs-CRP levels, and compared. Results The levels of serum adiponectin before treatment in ACI group were significantly lower than those in control group (P <0.05), while the levels of hs-CRP in ACI group were significantly higher than those in control group (P <0.05) Serum levels of adiponectin increased gradually in stroke subgroup, hs-CRP levels decreased in turn, the difference was statistically significant (P <0.05); serum adiponectin and hs-CRP levels were negatively correlated (r = 0.84, P <0.05). Conclusions The level of serum adiponectin and the level of hs-CRP in patients with atherosclerotic ACI are negatively correlated. The level of both is closely related to the size of cerebral infarction and the degree of neurological deficits.