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目的:了解2006～2010年广西出生缺陷医院监测网的围产儿先天性心脏病(CHD)变化趋势及影响因素,为政府制定干预措施提供依据。方法:对2006～2010年广西41所出生缺陷医院监测的围产儿CHD资料进行流行病学分析。结果:2006～2010年发现CHD围产儿994例,总发生率为26.44/万,年度发生率呈逐年上升趋势(χ2=30.192,P=0.00)。城镇与乡村围产儿CHD发生率比较差异有统计学意义(χ2=128.572,P=0.000);不同年份围产儿CHD转归的构成比差异有统计学意义。不同性别围产儿CHD发生率比较差异无统计学意义,男婴围产儿CHD的年度发生率呈逐年上升趋势(χ2=28.459,P=0.000);不同孕母年龄组比较差异有统计学意义(χ2=42.06,P=0.000),≥35岁孕母的围产儿CHD发生率最高,达36.71/万。结论:2006～2010年广西围产儿CHD发生率连续3年一直位居出生缺陷的首位。应通过加强健康教育,重点宣传出生缺陷防治的三道防线,提高孕妇自我保健意识,提高B超医师的诊断能力与诊断水平,早期发现、早期干预,减少出生缺陷发生率,建立CHD的跟踪随访管理机制,以提高CHD患儿的生存质量,降低患儿死亡率。
Objective: To understand the trend and influencing factors of perinatal congenital heart disease (CHD) in Guangxi Birth Defective Hospital Monitoring Network from 2006 to 2010, and provide basis for the government to make intervention measures. Methods: The epidemiological analysis of perinatal CHD data monitored in 41 birth-defect hospitals in Guangxi from 2006 to 2010 was conducted. Results: A total of 994 cases of perinatal CHD were found between 2006 and 2010, with a total incidence of 26.44 / million. The annual incidence rate showed an upward trend year by year (χ2 = 30.192, P = 0.00). The incidence of CHD in perinatal children in urban and rural areas was significantly different (χ2 = 128.572, P = 0.000). There were significant differences in the proportions of CHD among different years. There was no significant difference in the incidence of CHD among different sexes. The annual incidence of CHD in infants was increasing year by year (χ2 = 28.459, P = 0.000). There was significant difference in the age of CHM = 42.06, P = 0.000), the highest incidence of perinatal CHD occurred in 35-year-old pregnant mothers, reaching 36.71 / 10000. Conclusion: The incidence of CHD in perinatal infants in Guangxi from 2006 to 2010 has been the highest among birth defects for three consecutive years. We should strengthen health education by focusing on three lines of prevention and control of birth defects, raising pregnant women’s awareness of self-care, improving the diagnostic ability and diagnosis level of B-doctors, early detection and early intervention, reducing the incidence of birth defects and establishing follow-up of CHD Management mechanisms to improve the quality of life of children with CHD, reduce child mortality.