胆道闭锁(biliary atresia,BA)是一种由肝外胆道向肝内胆道进行性发展的闭锁纤维化病变,如不治疗,常导致新生儿胆汁淤积性肝硬化,并在出生后1年内夭折。肝移植是目前治愈BA的唯一有效方法,据统计,BA也是最常见的儿童肝移植的外科原因。BA病因学至今未明。各项研究表明,病毒感染、毒理作用和多基因突变等都可能与之有关。由于器官资源的稀缺,进一步了解BA的发病机制对寻找肝移植以 Biliary atresia (BA) is a type of ataxia of fibrosis developed progressively from the extrahepatic biliary tract to the intrahepatic biliary tract. If not treated, it often leads to cholestatic cirrhosis of the newborn and dies within 1 year after birth . Liver transplantation is currently the only effective treatment of BA, according to statistics, BA is also the most common surgical causes of liver transplantation in children. The etiology of BA is unknown. Various studies have shown that viral infections, toxicological effects and multiple gene mutations may be related. Due to the scarcity of organ resources, further understand the pathogenesis of BA on the search for liver transplantation