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Objective:To investigate the methylation status of the PCDH8 (Protocadherin-8) gene in gastric cancer tissues and find out the relationship between methylation status of the PCDH8 and clinicopathological features in gastric cancer patients.Methods:We first investigated the methylation status of the PCDH8 (Protoeadherin-8) gene in 65 gastric cancer and detected aberrant promoter methylation in gastric cancers; and then analyzed he relationship between methylation status of the PCDH8 and clinicopathological status with SPSS 13.0 software.Results:We first investigated the methylation status of the PCDH8 (Protocadherin-8) gene in 65 gastric cancer and detected aberrant promoter methylation in 36 of 65 (55.4％) gastric cancers.There was no significant difference in the distribution of patients with methylation or unmethylation of PCDH8 in terms of age,sex,tumor size,distant metastasis,or TNM stage.Methylation of PCDH8 was significantly correlated to negative pathological lymph node metastasis (P=0.038) and tumor differentiation (P=0.01).These two factors were proved to be of prognostic importance.Conclusion:Methylated PCDH8 seems to have a trend for worse prognosis in gastric cancer.However,a further large series of tumor samples and a longer follow-up period are required to elucidate its potential role.