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目的：利用大鼠胸主动脉球囊内皮剥脱术模型，探讨纤维蛋白（原）与肌内膜增殖的关系。方法：将６４只Ｗｉｓｔａｒ大鼠随机分为正常组、假手术组和剥脱组。剥脱组大鼠又分别在术后１０ｍｉｎ、１、３、７、１４、２１天处死取材。结果：大鼠胸主动脉免疫组织化学研究发现，正常组和假手术组大鼠血管壁无纤维蛋白（原）沉积，术后１０ｍｉｎ在血管腔表面即有一层致密的纤维蛋白（原）沉积，然后随着术后时间的延长，纤维蛋白（原）逐渐渗入到增殖的新生内膜中，中膜中未见有纤维蛋白（原）的沉积。结论：纤维蛋白（原）可能在内皮剥脱后的血管平滑肌细胞增殖中起一定作用。
OBJECTIVE: To explore the relationship between fibrin (prot) and endometrial hyperplasia by using rat aortic balloon endarterectomy model. Methods: Sixty-four Wistar rats were randomly divided into normal group, sham operation group and exfoliative group. The stripped rats were sacrificed at 10 min, 1, 3, 7, 14 and 21 days after operation. Results: Immunohistochemical study of thoracic aorta in rats showed that there was no deposition of fibrinogen in the vessel wall of rats in normal group and sham operation group, and a dense layer of fibrin (original) deposit on the surface of vascular lumen 10 min after operation. Then with the extension of postoperative time, fibrin (original) gradually infiltrated into proliferating neointima, and no deposition of fibrin (nephrogenic) was found in the media. Conclusion: Fibrin (prot) may play a role in the proliferation of vascular smooth muscle cells after endothelial exfoliation.