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目的探讨缺血性卒中对不宁腿综合征(RLS)发病率的影响及梗死部位与RLS之间的关系。方法选取2014年1—7月在该院神经内科就诊无RLS病史的172例卒中患者[平均年龄(67.38±7.56)岁]作为卒中组研究对象,通过影像学检查明确梗死部位。选取同期在该院体检中心体检的196名健康者[平均年龄(66.73±5.72)岁]作为对照组研究对象。通过一年的随访,比较二组研究对象RLS发病率及不同梗死部位对RLS发病率的影响。结果卒中组RLS发病率较对照组显著升高(P<0.05),相对危险度(RR)为4.56,95%的可信区间为3.966~5.249。基底节区梗死患者RLS发病例数与发病率均显著高于其他梗死部位(P<0.05)。结论缺血性卒中可显著增加RLS的发病风险,基底节区梗死是缺血性卒中引发RLS的关键因素。
Objective To investigate the effect of ischemic stroke on the incidence of Restless Legs Syndrome (RLS) and the relationship between infarct size and RLS. Methods A total of 172 stroke patients (mean age, 67.38 ± 7.56 years) with no history of RLS from January 2014 to July 2014 in our neurology department were enrolled in the stroke group. The infarct size was identified by imaging examination. A total of 196 healthy subjects (average age, 66.73 ± 5.72 years) who were examined at the same hospital during the same period as control group were selected as study subjects. Through one-year follow-up, the incidence of RLS and the incidence of RLS at different infarct sites were compared between the two groups. Results The incidence of RLS in stroke group was significantly higher than that in control group (P <0.05). The relative risk (RR) was 4.56, and the 95% confidence interval was 3.966-5.249. The incidence and incidence of RLS in patients with basal infarction were significantly higher than those in other infarcts (P <0.05). Conclusions Ischemic stroke can significantly increase the risk of RLS. Basal ganglia infarction is the key factor of RLS induced by ischemic stroke.