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应用小鼠骨髓嗜多染红细胞微核试验对食管癌高发区林县粮食中分离的圆弧青霉提取物进行了诱变性研究。结果:菌株7B_3的菌液和菌丝体提取物及菌株120B_1的菌液提取物在剂量为200mg/kg时,其微核率分别为:15.17±0.60‰,13.00±0.58‰和16.00±1.00‰,与溶剂对照(DM-SO,3.50±0.43%)相比有极显著性差异(P<0.01),并呈明显的剂量相关。菌株120B_1的菌丝体提取物在四个剂量组均没有引起微核率的显著增加。结果表明,圆弧青霉两种提取物中均含有诱变物质。
The mouse murine bone marrow polychromatic erythrocyte micronucleus test was used to study the mutagenicity of Penicillium cyclopium extracts isolated from Linxian County in the high incidence area of esophageal cancer. Results: The micronucleus rates of strain 7B_3 broth and mycelial extract and strain 120B_1 at the dose of 200mg/kg were: 15.17±0.60‰, 13.00±0.58‰ and 16.00±1.00‰, respectively. Compared with the solvent control (DM-SO, 3.50±0.43%), there was a significant difference (P<0.01), and there was a significant dose correlation. The mycelium extract of strain 120B_1 did not cause a significant increase in the micronucleus rate in all four dose groups. The results showed that both extracts of Penicillium cyclopium contained mutagenic substances.