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t(9;22),(q~(34);q~(11))为Ph染色体,是第一个特异与白血病相关的异常染色体,并在多数慢性髓细胞白血病(CML)中可检测到。CML的22号染色体断裂点在5.8Kb区,称主要断裂点集簇区(M-bcr),Ph~+的急性淋巴细胞白血病在M-bcr或bcr基因的第一个内含
t(9;22),(q~(34);q~(11)) is the Ph chromosome and is the first aberrant chromosome specifically related to leukemia, and is detectable in most chronic myeloid leukemia (CML) . CML has a chromosome 22 breakpoint in the 5.8 Kb region and is called the main breakpoint cluster region (M-bcr). Ph~+ acute lymphoblastic leukemia is contained in the first of the M-bcr or bcr genes.