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目的:研究尼群地平和阿司匹林在兔体外协同抗血小板聚集作用。方法:用比浊法观察尼群地平与阿司匹林对兔血小板聚集的协同作用。结果:尼群地平0.05~0.40mmol/L和阿司匹林0.54~4.34mmol/L剂量依赖性抑制胶原引起的血小板聚集;尼群地平0.10~0.40mmol/L和阿司匹林0.69~5.55mmol/L剂量呈依赖性抑制ADP引起的血小板聚集;尼群地平0.05~0.40mmol/L和阿司匹林0.01~0.07mmol/L也抑制花生四烯酸引起的血小板聚集,以上合并用药组Q值均等于或大于1。结论:尼群地平与阿司匹林合用在兔体外有协同抗血小板聚集作用。
OBJECTIVE: To study the synergistic antiplatelet aggregation effect of nitrendipine and aspirin in rabbits. Methods: The turbidimetric method was used to observe the synergistic effect of nitrendipine and aspirin on platelet aggregation in rabbits. Results: 0.05 ~ 0.40 mmol / L of nitrendipine and 0.54 ~ 4.34 mmol / L of aspirin inhibited platelet aggregation induced by collagen in a dose - dependent manner. Nitrendipine 0.10 ~ 0.40 mmol / L and aspirin 0 .69 ~ 5.55mmol / L dose-dependently inhibited ADP-induced platelet aggregation; nitrendipine 0.05 ~ 0.40mmol / L and aspirin 0.01 ~ 0.07mmol / L also inhibited arachidonic acid-induced Platelet aggregation, the above combination group Q values were equal to or greater than 1. Conclusion: Combination of nitrendipine and aspirin has synergistic effect on platelet aggregation in rabbits.