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目的：研究尼群地平和阿司匹林在兔体外协同抗血小板聚集作用。方法：用比浊法观察尼群地平与阿司匹林对兔血小板聚集的协同作用。结果：尼群地平０．０５～０．４０ｍｍｏｌ／Ｌ和阿司匹林０．５４～４．３４ｍｍｏｌ／Ｌ剂量依赖性抑制胶原引起的血小板聚集；尼群地平０．１０～０．４０ｍｍｏｌ／Ｌ和阿司匹林０．６９～５．５５ｍｍｏｌ／Ｌ剂量呈依赖性抑制ＡＤＰ引起的血小板聚集；尼群地平０．０５～０．４０ｍｍｏｌ／Ｌ和阿司匹林０．０１～０．０７ｍｍｏｌ／Ｌ也抑制花生四烯酸引起的血小板聚集，以上合并用药组Ｑ值均等于或大于１。结论：尼群地平与阿司匹林合用在兔体外有协同抗血小板聚集作用。
OBJECTIVE: To study the synergistic antiplatelet aggregation effect of nitrendipine and aspirin in rabbits. Methods: The turbidimetric method was used to observe the synergistic effect of nitrendipine and aspirin on platelet aggregation in rabbits. Results: 0.05 ~ 0.40 mmol / L of nitrendipine and 0.54 ~ 4.34 mmol / L of aspirin inhibited platelet aggregation induced by collagen in a dose - dependent manner. Nitrendipine 0.10 ~ 0.40 mmol / L and aspirin 0 .69 ~ 5.55mmol / L dose-dependently inhibited ADP-induced platelet aggregation; nitrendipine 0.05 ~ 0.40mmol / L and aspirin 0.01 ~ 0.07mmol / L also inhibited arachidonic acid-induced Platelet aggregation, the above combination group Q values were equal to or greater than 1. Conclusion: Combination of nitrendipine and aspirin has synergistic effect on platelet aggregation in rabbits.