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目的：观察赖诺普利对原发性高血压（ＥＨ）病人胰岛素敏感性的影响。方法：将５６例ＥＨ病人分成２组。赖诺普利组３１例（男性１６例，女性１５例，年龄４９ａ±ｓ１０ａ），给赖诺普利１０～２０ｍｇ，ｐｏ，ｑｄ×４ｗｋ；氢氯噻嗪组２５例（男性１３例，女性１２例，年龄５０ａ±１１ａ）给氢氯噻嗪２５～５０ｍｇ，ｐｏ，ｔｉｄ×４ｗｋ。结果：赖诺普利组降压总有效率为９４％与氢氯噻嗪组（９２％）相仿（Ｐ＞０．０５）。赖诺普利组空腹血糖与胰岛素均有明显降低（Ｐ＜０．０１）。代表胰岛素敏感性１／（ＦＰＧ×ＦＩＮＳ）的试验显著提高的差别有非常显著的意义（Ｐ＜０．０１），而在氢氯噻嗪组则均无此反应。结论：赖诺普利具有提高ＥＨ病人胰岛素敏感性的作用。
Objective: To observe the effect of lisinopril on insulin sensitivity in patients with essential hypertension (EH). Methods: 56 EH patients were divided into two groups. Lisinopril group of 31 patients (16 males and 15 females, age 49a ± s10a), to lisinopril 10 ~ 20mg, po, qd × 4wk; hydrochlorothiazide 25 patients (13 males and 12 females, Age 50a ± 11a) to hydrochlorothiazide 25 ~ 50mg, po, tid × 4wk. Results: The overall effective rate of lowering blood pressure in lisinopril group was 94% similar to that in hydrochlorothiazide group (92%) (P> 0.05). Fasting blood glucose and insulin were significantly lower in lisinopril group (P <0.01). There was a significant difference (P <0.01) in the significant difference between the tests indicating insulin sensitivity 1 / (FPG × FINS), but not in the hydrochlorothiazide group. Conclusion: Lisinopril has the effect of improving insulin sensitivity in EH patients.