目的:探讨脱嘌呤/脱嘧啶核酸内切酶1(Apurinic/apyrimidinic endonuclease-1,APE1)在糖尿病心肌病(diabetic cardiomyopathy,DCM)患者血清的表达改变和意义。方法:收集对照、糖尿病和DCM患者血清,ELISA法检测血清APE1的表达,FAM荧光标记法检测血清APE1的酶活性。结果:与对照组、糖尿病组相比,DCM组患者血清APE1的表达明显增加,而其DNA核酸内切酶活性显著降低。结论:表达增加而DNA修复功能减退的APE1可能参与糖尿病心肌病的发病过程。 Objective: To investigate the changes and significance of apurinic / apyrimidinic endonuclease-1 (APE1) in serum of patients with diabetic cardiomyopathy (DCM). Methods: The serum of control, diabetic and DCM patients was collected. The expression of APE1 in serum was detected by ELISA. The activity of APE1 in serum was detected by FAM fluorescent labeling. Results: Compared with control group and diabetic group, the expression of APE1 in DCM group was significantly increased and the DNA endonuclease activity was significantly decreased. CONCLUSIONS: APE1, which is expressed and DNA repair dysfunction may be involved in the pathogenesis of diabetic cardiomyopathy.