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摘要目的探寻和验证容积功能磁共振成像的疗效量化标准的最佳阈值,预测无法手术切除的肝细胞癌(HCC)病人经动脉介入治疗(IAT)后的总体生存情况。方法该研究经伦理委员会批准,免除病人的知情同意。共纳入HCC143例,均在IAT前及第Ⅰ期IAT后3~4周内行MRI检查。初次治疗后,运用专业软件分析肝细胞癌的特征性MR征象。病人随机分为实验组[n=114(79.7%)]和对照组[n=29(20.3%)]。运用单因素和多因素Cox模型确定不同组之间容积功能改变的最佳界值,以及生存率的差异。结果实验组中判断疗效改
Abstract Objective To explore and validate the optimal threshold of curative effect of volume functional magnetic resonance imaging to predict the overall survival of patients with unresectable hepatocellular carcinoma (HCC) after arterial intervention (IAT). Methods The study was approved by the ethics committee to dispense with patients’ informed consent. A total of 143 cases of HCC were enrolled. MRI examination was performed within 3 to 4 weeks after IAT and before IAT. After the initial treatment, the characteristic MR signs of hepatocellular carcinoma were analyzed using specialized software. Patients were randomly divided into experimental group [n = 114 (79.7%)] and control group [n = 29 (20.3%)]. Univariate and multivariate Cox models were used to determine the best cutoff of functional volume changes between groups and the difference in survival. Results in the experimental group to determine the efficacy of change