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目的观察氨氯地平对肾性高血压患者临床疗效。方法对９８例肾性高血压患者进行为期６周氨氯地平治疗。结果降压总有效率达９４．９％，收缩压（ＳＢＰ）与舒张压（ＤＢＰ）降压幅度分别为１３．８％与１８．１％，且提示降压达稳态与给药的持续时间有关，有效率随疗程的增加而增加；其降压治疗的同时，对尿蛋白亦有降低作用，但在连续用药６周后明显。其中６７例患者动态血压监测提示降压效应持续２４ｈ，ＳＢＰ与ＤＢＰ的降压谷峰比率分别为６９％与５６％，白昼与夜间降压幅度大致相等，２４ｈ心率无显著变化，对肝、肾功能、血脂代谢等无明显影响，副作用轻微，且发生于每天１０ｍｇ时。结论氨氯地平治疗肾性高血压，降压作用明显，对肾脏无损害作用，且服用方法简便，副作用小。
Objective To observe the clinical effect of amlodipine on patients with renal hypertension. Methods A total of 98 patients with renal hypertension were treated with amlodipine for 6 weeks. Results The total effective rate of antihypertensive was 94.9%, and the systolic blood pressure (SBP) and diastolic blood pressure (DBP) depressurization rates were 13.8% and 18.1%, respectively. Time-related, effective rate increased with the course of treatment increased; its antihypertensive treatment, while reducing the role of urinary protein, but after 6 weeks of continuous medication significantly. Among them, ambulatory blood pressure monitoring in 67 patients showed that the antihypertensive effect persisted for 24 hours, and the peak-to-peak trough ratio of SBP and DBP was 69% and 56% respectively. The amplitude of blood pressure during daytime and nighttime were almost the same, Function, blood lipid metabolism, no significant effect, minor side effects, and occurred in 10mg daily. Conclusion Amlodipine can treat renal hypertension with obvious antihypertensive effect and no harm to the kidneys. The method of taking amlodipine is simple and has few side effects.