论文部分内容阅读
目的:探索2型糖尿病(T2DM)大鼠颅骨极限骨缺损(CSD)的大小。方法:9周龄SD大鼠(体重300~320 g),用高脂高糖饲料+小剂量链脲佐菌素(STZ)腹腔注射诱导2型糖尿病模型,建模成功后,将糖尿病大鼠及正常大鼠各随机分为4组(n=3),分别于颅骨中央制备直径2、3、4、5 mm的骨缺损,术后8周取材,行大体观察、X线检查及组织学检测。结果:T2DM大鼠行颅骨缺损术后8周,直径2 mm的颅骨缺损愈合完全,X线阻射,组织学检测可见新骨生成良好;直径3、4、5 mm的颅骨缺损愈合不完整,X线透射,新骨生成不足。正常大鼠直径2、3、4 mm的缺损愈合完全,X线阻射,组织学检测可见新骨生成良好;直径5 mm的缺损未见愈合,X线透射,新骨生成较少。结论:T2DM大鼠颅骨极限骨缺损参考直径可定义为3 mm。
Objective: To explore the size of skull bone defect (CSD) in type 2 diabetic rats (T2DM). Methods: Nine-week-old Sprague-Dawley rats weighing 300-320 g were used to induce type 2 diabetes mellitus with high-fat, high-sugar and low-dose streptozotocin (STZ) .After modeling, And normal rats were randomly divided into 4 groups (n = 3). Bone defects with diameters of 2, 3, 4 and 5 mm were prepared in the central part of the skull respectively. Eight weeks after the operation, the specimens were taken for general observation, X-ray examination and histology Detection. Results: In the T2DM rats, skull defects of 2 mm in diameter healed completely at 8 weeks after operation. X-ray diffraction and histological examination showed that the new bone was well established. The defects of 3, 4 and 5 mm diameter calvarial defects healed incompletely, X-ray transmission, lack of new bone formation. In normal rats, defects of 2,3,4 mm in diameter healed completely. X-ray radiation and histological examination showed that new bone was well formed. No defect was found in 5 mm diameter of the defect, and X-ray transmission and new bone formation were less. Conclusion: The reference diameter of maximal skull defect in T2DM rats can be defined as 3 mm.