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慢性乙型肝炎病毒感染者约占全世界总人口的5％,本病是造成肝硬化的重要原因,并且与原发性肝癌有密切关联。抗病毒治疗最好能达到以下3种结果:1.完全清除病毒,HBsAz转阴,抗-HBs出现,肝脏病变完全消散,血清转氨酶恢复正常;2.慢性肝炎病情转向稳定,肝功能恢复正常,组织学病变好转,HBsAg可能仍为阳性;3.传染性降低或消失,如HBeAg阳性转为抗-HBe,DNA多聚酶活性减低或消失,血清抗-HBcIgM消失,血清及肝内游离的HBV-DNA消失。但是,目前所有的药物还不能使全部病例达到上述结果。
Chronic hepatitis B virus infection accounts for about 5% of the total population of the world, the disease is an important cause of cirrhosis, and is closely related with primary liver cancer. Antiviral therapy is best to achieve the following three kinds of results: 1. Complete removal of the virus, HBsAz negative, anti-HBs appeared, the liver lesions completely dissipated, serum aminotransferase returned to normal; 2. The condition of chronic hepatitis turned stable, liver function returned to normal, Histopathological improvement, HBsAg may still be positive; 3. Infectious decreased or disappeared, such as HBeAg-positive to anti-HBe, DNA polymerase activity decreased or disappeared, serum anti-HBcIgM disappeared, serum and liver free HBV-DNA disappear. However, all the current drugs can not achieve the above results in all cases.