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目的研究对轻度子痫前期患者联合应用低分子抗氧化剂对自由基及出生婴儿窒息的影响。方法收集病例为同一时期入院患者,包括孕龄及患者年龄等一般资料无显著差异的单胎120例,其中正常妊娠60例,轻度子痫前期患者60例;分别检测患者的脐血中丙二醛(MDA)、维生素E、维生素C、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)等5项指标,将轻度子痫前期患者60例再次随机分为实验组与对照组各30例,实验组在常规治疗的联合应用维生素C、GSH、维生素E 100 mg治疗。对照组为硫酸镁常规治疗,在观察5项指标的同时观察出生婴儿的窒息发生率,将5项指标及出生婴儿的窒息发生率进行统计学研究。结果实验组组患者血中MDA水平下降(P<0.01),而GSH、维生素E、维生素C(P<0.01)上升,SOD无变化(P>0.05)。出生婴儿窒息发生率明显低于对照组。结论在常规治疗的基础上联合应用维生素C、GSH、维生素E等低分子抗氧化剂可减少轻度子痫前期患者的自由基损伤,同时也降低了出生婴儿窒息率。
Objective To study the effect of combined use of low molecular weight antioxidants on asphyxia of free radicals and born infants in patients with mild preeclampsia. Methods Totally 120 cases of singleton without any significant difference in general information such as gestational age and patient’s age were included in the study. Among them, 60 cases were normal pregnancy and 60 cases were mild preeclampsia. Dialysate (MDA), vitamin E, vitamin C, glutathione (GSH) and superoxide dismutase (SOD). Sixty patients with mild preeclampsia were randomly divided into experimental group and control group 30 cases in each group. The experimental group was treated with 100 mg vitamin C, GSH and vitamin E in the routine treatment. The control group was routinely treated with magnesium sulfate. The incidence of asphyxia of infants was observed while 5 indicators were observed. The incidence of asphyxia of 5 indicators and infants was statistically analyzed. Results The level of MDA in the blood of experimental group decreased (P <0.01), while the levels of GSH, vitamin E and vitamin C (P <0.01) did not change (P> 0.05). The incidence of neonatal asphyxia was significantly lower than that of the control group. Conclusion The combination of routine treatment with vitamin C, GSH, vitamin E and other low molecular weight antioxidants can reduce the mild radical preeclampsia patients with free radical damage, but also reduce the birth rate of asphyxia.