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目的:通过检测新疆地区甲状腺乳头状癌组织及甲状腺良性病变组织中DAPK1和RARβ的蛋白表达特点,探讨其在甲状腺乳头状癌发生发展中的意义。方法:采用免疫组织化学S-P法,检测DAPK1与RARβ在新疆地区38例甲状腺乳头癌、21例甲状腺良性腺瘤、13例桥本氏甲状腺炎、6例结节性甲状腺肿和6例癌旁正常甲状腺组织中的蛋白表达,并分析其与临床病理因素间的关系。结果:DAPK1在甲状腺乳头状癌中的阳性表达明显低于甲状腺腺瘤、桥本氏甲状腺炎、结节性甲状腺肿和癌旁正常甲状腺组织(P<0.01);RARβ在甲状腺乳头状癌中的阳性表达明显高于在甲状腺良性腺瘤、桥本氏甲状腺炎、结节性甲状腺肿和癌旁正常甲状腺组织(P<0.01);DAPK1与RARβ在甲状腺乳头状癌中的表达与患者的年龄、性别、民族无明显相关关系(P>0.05)。结论:DAPK1可能参与了甲状腺乳头状癌的发生发展过程。检测DAPK1和RARβ的表达水平可作为判断甲状腺乳头状癌转移和预后的参考指标。
OBJECTIVE: To investigate the protein expression of DAPK1 and RARβ in thyroid papillary carcinoma and thyroid benign lesions in Xinjiang and its significance in the development of papillary thyroid carcinoma. Methods: Immunohistochemical SP method was used to detect 38 cases of thyroid papillary carcinoma, 21 cases of thyroid benign adenoma, 13 cases of Hashimoto’s thyroiditis, 6 cases of nodular goiter and 6 cases of normal adjacent tissues in Xinjiang region by DAPK1 and RARβ Thyroid tissue protein expression, and analysis of its relationship with clinicopathological factors. Results: The positive expression of DAPK1 in thyroid papillary carcinoma was significantly lower than that in thyroid adenoma, Hashimoto’s thyroiditis, nodular goiter and normal parathyroid tissue (P <0.01). The positive rate of RARβ in thyroid papillary carcinoma (P <0.01). The expression of DAPK1 and RARβ in thyroid papillary carcinoma was positively correlated with the age of the patients, the positive expression of DAPK1 and RARβ in thyroid adenoma, Hashimoto’s thyroiditis, nodular goiter and adjacent normal thyroid tissue Gender, ethnic no significant correlation (P> 0.05). Conclusion: DAPK1 may be involved in the development of papillary thyroid carcinoma. Detection of DAPK1 and RARβ expression levels can be used as a reference to determine thyroid papillary carcinoma metastasis and prognosis.