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目的:探讨慢性充血性心力衰竭患者血清基质金属蛋白-2(MMP-2)水平变化规律及其临床意义。方法:将120例慢性心力衰竭患者作为观察组,体检健康者80例作为对照组,比较两组MMP-2水平的差异,同时观察慢性心力衰竭不同分级指标升高情况及其与脑钠肽(BNP)水平的相关性。结果:观察组MMP-2水平显著高于对照组(P<0.05),且随着心功能分级的升高而增加(P<0.05)。血清MMP-2水平与LVEF、LVEDV、BNP水平呈正相关(P<0.05)。结论:MMP-2水平与慢性心力衰竭的发生具有明显相关性,有一定的临床意义。
Objective: To investigate the change of serum matrix metalloproteinase-2 (MMP-2) level and its clinical significance in patients with chronic congestive heart failure. Methods: 120 cases of chronic heart failure patients as observation group and 80 healthy subjects as control group. The difference of MMP-2 level between the two groups was compared. At the same time, the different grade indexes of chronic heart failure and the relationship with brain natriuretic peptide BNP) levels. Results: The level of MMP-2 in observation group was significantly higher than that in control group (P <0.05), and increased with the increase of cardiac function (P <0.05). Serum MMP-2 level was positively correlated with LVEF, LVEDV and BNP (P <0.05). Conclusion: The level of MMP-2 is significantly correlated with the occurrence of chronic heart failure and has certain clinical significance.