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目的探讨不稳定性心绞痛患者外周血CD4+CD25+调节性T细胞(Treg)水平及意义。方法采用流式细胞分析法,检测13例不稳定性心绞痛患者、8例稳定性心绞痛患者和10例胸痛综合征患者外周血CD4+CD25+Treg占CD4+T细胞比例。结果不稳定性心绞痛患者外周血 Treg/CD4+T细胞比例(10．1±3．4％)显著低于稳定性心绞痛组(14．2±2．9％)和胸痛综合征组 (16．5±4．9％)。结论不稳定性心绞痛患者外周血Treg比例减少。Treg比例降低可能打破了外周免疫耐受,参与了动脉粥样硬化的发生发展。
Objective To investigate the level of CD4 + CD25 + regulatory T cells (Treg) in peripheral blood of patients with unstable angina pectoris and its significance. Methods Flow cytometry was used to detect the percentage of CD4 + CD25 + Treg in CD4 + T cells in peripheral blood of 13 patients with unstable angina, 8 patients with stable angina, and 10 patients with chest pain syndrome. Results The proportion of Treg / CD4 + T cells in peripheral blood of patients with unstable angina (10.1 ± 3.4%) was significantly lower than that of patients with stable angina (14.2 ± 2.9%) and chest pain syndromes (16. 5 ± 4.9%). Conclusion The proportion of Treg in the peripheral blood of patients with unstable angina decreases. Decreased proportion of Treg may break the peripheral immune tolerance, involved in the development of atherosclerosis.