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目的观察1%联苯苄唑乳膏联合20%尿素软膏治疗角化型足癣临床和真菌学疗效。方法治疗组34例角化型足癣患者采用1%联苯苄唑乳膏联合20%尿素乳膏治疗。对照组30例只用1%联苯苄唑乳膏,疗程均为4周。结果症状总积分,治疗组由治疗前(8.83±1.66)降至(1.23±0.72);对照组由(9.15±1.30)降至(2.63±2.51),两组差异有统计学意义(t=3.18,P<0.01)。治愈率、有效率治疗组和对照组分别为:61.70%、96.99%和46.67%、70.00%,两组有效率差异有统计学意义(χ2=8.85,P<0.01)。结论联苯苄唑乳膏联合20%尿素软膏治疗角化型足癣疗效优与联苯苄唑乳膏。
Objective To observe the clinical and mycological effects of 1% bifonazole cream combined with 20% urea ointment in the treatment of keratosis tinea pedis. Methods 34 cases of keratinized tinea pedis were treated with 1% bifonazole cream and 20% urea cream. Control group, 30 cases only 1% bifonazole cream, treatment were 4 weeks. Results The total score of the treatment group decreased from (8.83 ± 1.66) to (1.23 ± 0.72) before treatment and from (9.15 ± 1.30) to (2.63 ± 2.51), the difference was statistically significant (t = 3.18 , P <0.01). The cure rate and effective rate were 61.70%, 96.99% and 46.67% in the treatment group and 70.00% in the control group, respectively. The differences between the two groups were statistically significant (χ2 = 8.85, P <0.01). Conclusion Bifonazole cream combined with 20% urea ointment in the treatment of keratinized tinea pedis is superior to bifonazole cream.