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目的 探讨血清脂蛋白 (a) [L p(a) ]含量增高与青年人脑梗死的危险因素及其脑梗死部位的关系。方法 采用酶联免疫吸附法检测 5 4例青年人脑梗死患者 L p(a)含量 ,并与 40名正常对照者进行比较。结果 青年脑梗死患者血清中 L p(a)含量及其异常率显著高于对照组 ,其中皮质支动脉闭塞 (CAO)亚组亦显著高于深穿支动脉闭塞 (PAO)亚组。L p(a)含量与血清总胆固醇、甘油三酯及血糖之间无相关性 ,不受性别、高血压、冠心病、吸烟、卒中家族史及合并危险因素的多少等因素的影响。结论 血清 L p(a)含量增高是青年人脑梗死尤其是 CAO的重要的独立危险因素。
Objective To investigate the relationship between elevated levels of serum lipoprotein (a) [L p (a)] and risk factors for cerebral infarction in young adults. Methods The level of Lp (a) in 54 young patients with cerebral infarction was detected by enzyme-linked immunosorbent assay and compared with 40 normal controls. Results The levels of Lp (a) and its abnormalities in serum of young patients with cerebral infarction were significantly higher than those of the control group. The subgroup of cortical branch artery occlusion (CAO) was also significantly higher than the subgroup of deep perforating artery occlusion (PAO). There was no correlation between Lp (a) level and serum total cholesterol, triglyceride and blood glucose, and was not affected by such factors as gender, hypertension, coronary heart disease, smoking, family history of stroke and the risk factors of the combination. Conclusion The increase of serum Lp (a) level is an important independent risk factor for cerebral infarction especially CAO in young people.