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目的研究Rho相关卷曲螺旋蛋白激酶2(ROCK2)在非小细胞肺癌中的表达及其临床意义。方法利用免疫组织化学方法检测90例非小细胞肺癌组织及其配对的癌旁正常肺组织中ROCK2表达水平。分析其表达与临床病理学特征的关系。结果 ROCK2在90例非小细胞肺癌组织中的表达率为40%。有无吸烟史组、有无淋巴结转移组的ROCK2表达比较差异有统计学意义(P<0.05)。TNMⅠ期、Ⅱ期、Ⅲ~Ⅳ期病变组的ROCK2的阳性表达率分别为21.74%、45.45%、72.73%,三者间比较差异有统计学意义(P<0.01)。结论 ROCK2在非小细胞肺癌组织中的表达高低与患者吸烟与否、有无淋巴结转移及肿瘤的分化程度相关。
Objective To investigate the expression of Rho-associated coiled-coil protein kinase 2 (ROCK2) in non-small cell lung cancer and its clinical significance. Methods Immunohistochemical method was used to detect the expression of ROCK2 in 90 non-small cell lung cancer tissues and paired adjacent normal lung tissues. Analysis of the relationship between its expression and clinicopathological features. Results The expression of ROCK2 in 40 non-small cell lung cancer tissues was 40%. There was significant difference in the expression of ROCK2 with or without smoking history group (P <0.05). The positive expression rates of ROCK2 in stage Ⅰ, stage Ⅱ, stage Ⅲ ~ Ⅳ of TNM were 21.74%, 45.45%, 72.73% respectively, with statistical significance (P <0.01). Conclusion The expression level of ROCK2 in non-small cell lung cancer is related to smoking or not, lymph node metastasis and the degree of tumor differentiation.