Objective: To examine the association between a lifetime history of migraines and other headaches with and without aura and Rose angina and coronary heart di sease (CHD). Methods: Participants were 12,409 African American and white men an d women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting ≥ 4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headac hes). Gender-specific associations of headaches with Rose angina and CHD, adju sted for sociodemographic and cardiovascular disease risk factors, were evaluate d using Poisson regression. Results: Participants with a history of migraines an d other headaches were more likely to have a history of Rose angina than those w ithout headaches. The associations were stronger for mi graine and other headaches with aura (prevalence ratio [PR] = 3.0, 95% CI = 2.4, 3.7 and PR = 2.0, 95% CI = 1.5, 2.7 for women; PR = 2.2, 95% CI = 1.2, 3.9 and PR = 2.4, 95% CI = 1.4, 3.9 for men) than for migraine and other head aches without aura (PR = 1.5, 95% CI = 1.2, 1.9 and PR = 1.3, 95% CI = 1.1, 1.6 for women; PR = 1.9, 95% CI = 1.2, 2.9 and OR = 1.4, 95% CI = 1.0, 1.8 f or men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura. Conclusions: The lack of association of mig raines with coronary heart disease suggests that the association of migraine wit h Rose angina is not related to coronary artery disease. Future research assessi ng other common underlying pathologic mechanisms is warranted. Objective: To examine the association between a lifetime history of migraines and other headaches with and aura and Rose angina and coronary heart diase (CHD). Methods: Participants were 12,409 African American and white men an d women from the Atherosclerosis Risk in Communities Study, categorized by their lifetime history of headaches lasting ≥ 4 hours (migraine with aura, migraine without aura, other headaches with aura, other headaches without aura, no headac hes). Gender-specific associations of headaches with Rose angina and CHD, adju sted for sociodemographic and cardiovascular disease risk factors, were evaluated d using Poisson regression. Results: Participants with a history of migraines an d other headaches were more likely to have a history of Rose angina than those w ithout headaches. graine and other headaches with aura (prevalence ratio [PR] = 3.0, 95% CI = 2.4, 3.7 and PR = 2.0, 95% CI = 1.5, 2.7 for women; 95% CI = 1.4, 3.9 for men) than for migraine and other head aches without aura (PR = 1.5, 95% CI = 1.2, 1.9 and PR = 1.3, 95% CI = 1.1, 1.6 for women; PR = 1.9, 95% CI = 1.2, 2.9 and OR = 1.4, 95% CI = 1.0, 1.8 f or men). In contrast, migraine and other headaches were not associated with CHD, regardless of the presence of aura. Conclusions: The lack of association of mig raines with coronary heart disease suggests that the association of migraine wit h Rose angina is not related to coronary artery disease. Future research assessi ng other common underlying pathologic mechanisms is warranted.