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目的:对肥胖型轻中度高血压进行氨氯地平、二甲双胍治疗的临床效果。方法:选择2015年5月至2016年11月佛山市南海区第七人民医院收治肥胖型轻中度高血压患者102例,随机分成观察组和对照组,每组各51例,对照组肥胖型轻中度高血压患者单独使用氨氯地平药物治疗,观察组联合氨氯地平与二甲双胍2种药物共同治疗。对比两组肥胖型轻中度高血压患者各项指标情况。结果:观察组肥胖型轻中度高血压患者血压指标明显优于对照组,差异具有统计学意义(P<0.05);观察组患者空腹血糖(5.12±0.83)mmol·L~(-1)、空腹胰岛素(15.13±0.64)m U·L~(-1)、胰岛素敏感指数(2.26±0.47)明显优于对照组,差异具有统计学意义(P<0.05)。结论:联合氨氯地平与二甲双胍两种药物共同治疗,可有效控制肥胖型轻中度高血压的血压水平,对改善患者血糖、胰岛素水平具有显著效果。
OBJECTIVE: To evaluate the clinical efficacy of amlodipine and metformin in obese mild to moderate hypertension. Methods: From May 2015 to November 2016, 102 patients with obesity-type mild-moderate hypertension were admitted to the Seventh People’s Hospital of Nanhai District, Foshan City. They were randomly divided into observation group and control group, with 51 cases in each group. The control group was obese Patients with mild-to-moderate hypertension were treated with amlodipine alone, and those in the observation group were treated with amlodipine and metformin. The two groups of obese patients with mild to moderate hypertension were compared. Results: The blood pressure of obese mild to moderate hypertensive patients in the observation group was significantly better than that of the control group (P <0.05). The fasting blood glucose (5.12 ± 0.83) mmol·L -1, Fasting insulin (15.13 ± 0.64) m U · L -1, insulin sensitivity index (2.26 ± 0.47) was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion: The combination of amlodipine and metformin can effectively control the blood pressure of obese patients with mild to moderate hypertension, and has a significant effect on improving blood glucose and insulin level in patients.