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[目的]探讨右美托咪定(Dex)对胆汁淤积大鼠肝脏缺血再灌注损伤(IRI)的影响.[方法] 将24只采用胆总管结扎法制作的胆汁淤积模型大鼠随机分为三组(n =8):假手术组(A组)、肝脏缺血再灌注组(B组)、Dex组(C组).应用Pringle法阻断肝门,30 min后解除阻断并关腹,4 h后处死大鼠,取血清检测总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)及肿瘤坏死因子-α(TNF-α)水平,取肝组织匀浆检测超氧化物歧化酶(SOD)、丙二醛(MDA)水平,并取肝组织病理切片 HE染色观察形态学改变.[结果]阻断解除后4 h,三组大鼠血清TBIL及DBIL水平比较差异无显著性(P >0.05);B组大鼠血清ALT、AST、TNF-α水平及肝组织MDA含量均高于A组(P <0.05),B组大鼠肝组织SOD活性显著低于A组(P<0.05);C组大鼠血清AST,TNF-α水平及肝组织MDA含量均低于B组(P 0.05).Serum ALT,AST and TNF-α levels,tissue MDA contents in the B group were significantly higher than those in the A group(P <0.05).Tissue SOD activities in the B group were significantly lower than the A group(P <0.05).Serum AST and TNF-α levels,tissue MDA contents in the C group were signif-icantly lower than the B group(P <0.05).Histopathological changes(liver tissue destruction,hepatic cord disorders and inflammatory cell infiltration)in the B group were more obvious than in the A and C groups.[Conclusion] Dexmedetomidine may attenuate hepatic IRI injury in cholestatic rats,possibly by alleviating systemic inflammation and oxidative stress.