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目的探讨预防性放化疗对食管癌根治术后淋巴结复发时间的影响。方法选取食管癌根治术后淋巴结复发患者132例(术前未进行新辅助治疗)。其中,未进行预防性放化疗74例,进行预防性放化疗58例(放疗或放化疗19例,化疗39例)。根据术后病理报告了解T分期,分析预防性放化疗对淋巴结复发时间的影响。结果 132例中,淋巴结复发时间为1~107个月,中位复发时间15.0个月。预防性放化疗对术后淋巴结病理阴性、早T(0.05);对晚T及淋巴结阳性患者,预防性放化疗可延缓淋巴结复发时间(P<0.05)。结论预防性放化疗对食管癌根治术淋巴结阳性患者及晚T患者有延缓复发时间的作用,但对淋巴结阴性及早T患者的复发时间无改善。
Objective To investigate the effect of preventive radiotherapy and chemotherapy on lymph node recurrence after radical operation of esophageal cancer. Methods 132 patients with recurrent lymph node after radical resection of esophageal cancer were selected (no neoadjuvant therapy was performed before operation). Among them, there were 74 cases without preventive chemoradiotherapy and 58 cases with chemoradiation (radiotherapy or chemoradiotherapy in 19 cases and chemotherapy in 39 cases). According to postoperative pathological reports to understand T staging, analysis of preventive radiotherapy and chemotherapy on lymph node recurrence time. Results In 132 cases, the recurrence time of lymph nodes was from 1 to 107 months, and the median recurrence time was 15.0 months. Prophylactic chemoradiation had no effect on lymph node recurrence after operation (P> 0.05), but no effect on chemoradiotherapy (P> 0.05). Preoperative chemoradiation could delay lymph node recurrence in patients with late T and lymph node positive (P < 0.05). Conclusion Prophylactic radiotherapy and chemotherapy have the effect of delaying relapse time in patients with positive lymph nodes and late T patients with esophageal cancer, but there is no improvement in the recurrence time of patients with negative and early T lymph nodes.