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近年不少工作表明,除甾体(如雌激素和孕酮)外,卵巢中还有其他因素控制着卵巢周期活动中促性腺激素浓度的变化。其中之一是曾在大家畜和人的滤泡液中找到的一种特异性抑制卵泡刺激素(FSH)释放的蛋白质,可能就是在睾丸分泌液中发现的抑制素(inhibin)样物质,其具有在大鼠动情周期中调节FSH分泌的生理作用。有人报告过含有类抑制素样活性的制剂在体外试验中可抑制自发的FSH释放与合成,亦可抑制由黄体生成素释放激素(LH-RH)刺激所引起的FSH分泌。这些制剂在体内也有同样的作用,并认为它不仅可直接干扰FSH由垂体的释放也可作用于下丘脑水平所引起的FSH释放。本文研究了一种制剂——
In recent years, a lot of work shows that in addition to steroids (such as estrogen and progesterone), there are other factors in the ovary that control the ovarian cycle activity gonadotropin concentration changes. One of them is a protein that specifically inhibits the release of follicle-stimulating hormone (FSH), found in follicular fluid from large livestock and humans, probably the inhibin-like substance found in testis secretions, which Has the physiological role of regulating FSH secretion during the rat estrus cycle. It has been reported that formulations containing statin-like activity inhibit spontaneous release and synthesis of FSH in vitro and also inhibit FSH secretion stimulated by luteinizing hormone-releasing hormone (LH-RH). These preparations also have the same effect in the body and are believed to not only directly interfere with the FSH release of FSH caused by pituitary and hypothalamic levels. This article studies a formulation -