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目的：观察左氧氟沙星联合治疗复治菌阳肺结核病的临床疗效。方法：将90例复治菌阳肺结核患者随机分为治疗组及对照组各45例。化疗方案：治疗组在采用常规抗结核药（利福平、异烟肼、吡嗪酰胺、乙胺丁醇）治疗的同时，加用左氧氟沙星治疗；对照组单纯予常规抗结核药治疗，疗程均为8个月。观察病灶吸收、空洞关闭、痰菌阴转情况及该药不良反应。结果：治疗期满治疗组痰菌阴转率为90.4%，对照组痰菌阴转率为56.8%；治疗组病灶吸收总有效率88.1%，对照组病灶吸收总有效率59.1%；治疗组空洞闭合或缩小35例（83.3%），对照组空洞闭合或缩小20例（45.4%），治疗组明显高于对照组，两组间差异有显著性（p0.05）。结论：左氧氟沙星联合治疗复治菌阳肺结核病可明显提高痰菌阴转率，促进病灶吸收，疗效满意，不良反应小，有较高的临床推广价值。“,”Objective To observe the clinical curative effect of levofloxacin on retreated sputum positive pulmonary tuberculosis. Methods 90 cases of sputum positive pulmonary tuberculosis patients were randomly divided into treatment group and control group with 45 cases in each group. Chemotherapy: in the treatment group with conventional anti tuberculosis drugs (Li Fuping, isoniazid, ethambutol, pyrazinamide) treatment at the same time, combined with levofloxacin therapy; the control group treated by routine anti tuberculous drug therapy, treatment for 8 months. Observation of focus absorption, cavity closure, the sputum negative conversion rate and the drug adverse reaction.Results The treatment group the treatment expires the sputum negative conversion rate was 90.4%, control group, the sputum negative conversion rate was 56.8%; the treatment group focus absorption in the total efficiency of 88.1%, control group focus absorption in the total efficiency of 59.1%; the treatment group cavity closure or reduced in 35 cases (83.3%), the control group of cavity closure or reduced in 20 cases (45.4%) the treatment group was significantly higher than that in the control group, and there was significant difference between two groups (P 0.05).Conclusion Levofloxacin on Retreatment Smear Positive Pulmonary tuberculosis can obviously improve the sputum negative conversion rate, promote the focus absorption, satisfactory curative effect, less adverse reactions, higher clinical value.