头颅创伤、脑卒中、脑肿瘤、颅内感染以及各种原因所致呼吸、心跳骤停均可伴有脑水肿的发生,严重者可危及患者生命。水通道蛋白-4(AQP4)作为主要在脑组织中表达的水通道蛋白,起着调节脑内水转运的重要功能,参与脑水肿的病理生理过程,提示调节水通道蛋白-4表达水平可能为减轻各类中枢神经系统损伤后脑水肿提供新的治疗途径。 Head trauma, stroke, brain tumors, intracranial infections and various causes of respiratory arrest, cardiac arrest may be associated with cerebral edema, severe cases can endanger the lives of patients. Aquaporin-4 (AQP4), an aquaporin that is mainly expressed in brain tissue, plays an important role in the regulation of water transport in the brain and participates in the pathophysiological processes of brain edema, suggesting that the regulation of aquaporin-4 expression may be Reduce various types of central nervous system injury after brain edema provide a new therapeutic approach.