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目的探讨鼻腔软骨-骨呼吸上皮性腺瘤样错构瘤(COREAH)临床病理特点。方法报道1例鼻腔软骨-骨呼吸上皮性腺瘤样错构瘤,回顾分析其临床、影像学、病理组织学特点,探讨其诊断及鉴别诊断。结果患儿3岁,男性,鼻塞伴脓涕6个月。鼻腔镜检查示左侧鼻腔粉红色新生物,堵满整个左鼻道。MRI示左鼻腔后筛和嗅裂来源肿物,未见骨质破坏。组织学表现为息肉样病变,纤维黏液样间质,被覆假复层纤毛柱状上皮,上皮下见增生的呼吸上皮性腺体,囊性扩张,周围见散在软骨岛。间质内少量淋巴浆细胞浸润。结论 COREAH是一种少见的鼻腔错构瘤,常见于儿童。大体表现为息肉样病变,组织病理诊断关键在于同时具有呼吸上皮性腺体和软骨或骨成分。
Objective To investigate the clinicopathological features of nasal cavity cartilage - bone resorptive epithelial adenomatous hamartoma (COREAH). Methods One case of nasal cartilage-bone resorptive epithelial adenoma-like hamartoma was reported. The clinical, imaging and histopathological features of the nasal cavity were retrospectively analyzed. The diagnosis and differential diagnosis were also discussed. Results 3-year-old children, male, nasal congestion with purulent tears 6 months. Nasal examination revealed nasal pink new creatures, plugging the entire left nasal passages. MRI showed left nasal sieve and olfactory fissure origin of the tumor, no bone destruction. Histological findings of polypoid lesions, fibrous myxoid stroma, pseudostratified covered ciliated columnar epithelium, epithelial see the proliferation of respiratory epithelial glands, cystic dilatation, scattered around see the cartilage island. A small amount of interstitial lymphocyte plasma infiltration. Conclusion COREAH is a rare nasal hamartoma common in children. The general performance of polypoid lesions, histopathological diagnosis is the key to both respiratory epithelial glands and cartilage or bone composition.