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肿瘤生长的前提是一个新血管形成的过程,后者由一些肿瘤细胞或非恶性细胞产生并可以渗透入肿瘤的因子来诱导。已证明胸苷磷酸化酶(TP)是一种血小板源内皮细胞生长因子,在血管生成中起作用。现发现许多类型的肿瘤中免疫组化TP表达与临床病理因素和/或预后有关。应用免疫组化分析方法对子宫内膜癌细胞中TP表达与肿瘤中微血管密度、临床病理特征及预后的相关性进行研究。
The premise of tumor growth is a process of neovascularization induced by factors that are produced by some tumor cells or non-malignant cells and that can penetrate into the tumor. Thymidine phosphorylase (TP) has been shown to be a platelet-derived endothelial cell growth factor that plays a role in angiogenesis. Immunohistochemical TP expression in many types of tumors has been found to be associated with clinical pathological factors and/or prognosis. Immunohistochemical analysis was used to investigate the correlation of TP expression in endometrial cancer cells with microvessel density, clinicopathological features, and prognosis in tumors.