论文部分内容阅读
小细胞肺癌(small cell lung cancer,SCLC)占肺癌的10%~20%,恶性程度高,易转移复发。SCLC具有易发生脑转移的临床生物学特征,而随着现代综合诊疗的进步,患者生存率逐渐提高,相应的脑转移发生率也逐渐增加。治疗后完全缓解的局限期SCLC患者可从预防性脑照射(prophylactic cranial irradiation,PCI)中获益,但高龄患者以及完全切除的早期患者行PCI的必要性,尚存在争议。此外,PCI的适用人群范围、介入时机、剂量分割、远期神经毒副作用仍有待进一步研究。全文对上述问题进行文献综述,并介绍该领域的研究进展。
Small cell lung cancer (SCLC) accounts for 10% to 20% of lung cancer, with a high degree of malignancy and easy metastasis and recurrence. SCLC has the clinical biological characteristics of prone brain metastases, and with the progress of modern comprehensive diagnosis and treatment, patient survival rate gradually increased, the corresponding increase in the incidence of brain metastases. Limited duration of post-treatment SCLC patients may benefit from prophylactic cranial irradiation (PCI), but the need for PCI in elderly patients and in early-stage patients undergoing total resection remains controversial. In addition, the scope of PCI for the crowd, intervention timing, dose division, long-term side effects of neurotoxicity remains to be further studied. The full text of the literature review of the above issues, and introduce the research progress in this area.