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目的:提高对新生儿神经母细胞瘤临床特征及预后的认识。方法:对2010年7月至2015年3月中国医科大学附属第四医院儿科收治的8例新生儿神经母细胞瘤患儿的临床表现、组织病理分型、治疗及预后进行回顾性分析。结果:患儿中男性5例,女性3例,发病年龄孕24周至生后28天,中位数年龄9天。原发肿瘤4例位于左肾上腺,2例位于右肾上腺,1例位于双肾上腺,1例位于盆腔。6例经肿瘤组织病理学确诊,2例经骨髓细胞学确诊。临床分期:1期1例,2期1例,4S期6例。5例给予原发肿瘤切除和术后化疗,1例给予一侧原发肿瘤切除和术后化疗,2例仅给予化疗。8例均生存,随访时间6~56个月,6例均达持续完全缓解,2例带瘤生存。结论:新生儿神经母细胞瘤具有自身生物学特性,临床分期主要为1期、2期和4S期,病理分型多数是神经母细胞瘤,预后良好。
Objective: To improve the understanding of the clinical features and prognosis of neonatal neuroblastoma. Methods: The clinical manifestations, histopathological types, treatment and prognosis of 8 neonates with neuroblastoma admitted to the Fourth Affiliated Hospital of China Medical University from July 2010 to March 2015 were retrospectively analyzed. Results: There were 5 males and 3 females with the age of 24 weeks to 28 days and the median age of 9 days. Four cases of primary tumors were located in the left adrenal gland, two in the right adrenal gland, one in the adrenal gland, and one in the pelvic cavity. 6 cases were diagnosed by histopathology and 2 cases by bone marrow cytology. Clinical stage: 1 case in stage 1, 2 cases in 1 case and 4 cases in 6 cases. Five cases were given primary tumor resection and postoperative chemotherapy, one case was given primary tumor resection and postoperative chemotherapy, and two cases were given only chemotherapy. All the 8 patients survived for 6 ~ 56 months. All 6 patients achieved sustained and complete remission, and 2 patients survived. Conclusion: Neonatal neuroblastoma has its own biological characteristics. The main clinical stages are stage 1, stage 2 and stage 4S. Most of the pathological types are neuroblastoma with good prognosis.