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目的:分析炎琥宁不良反应的发生情况及临床特点,为其合理用药提供参考。方法:检索2006年以来中国学术期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)收载的注射用炎琥宁不良反应文献,以及2015年国家药品不良反应监测中心病例报告数据库登记的不良反应信息,进行统计分析。结果:文献共报道炎琥宁不良反应653例次;其年龄分布以0~17岁较多(398例,61%);多发生在用药后30 min内(510例,78%);累及的器官或系统较多,以皮肤及其附件损害和全身性损害多见(358例,51%);不良反应结局绝大多数是治愈和好转(605例,92.6%),未发现死亡病例报告。结论:临床合理使用炎琥宁的同时,应加强用药监测,以减少不良反应的发生。
Objective: To analyze the occurrence and clinical characteristics of the side effects of mesylate and provide references for its rational use. Methods: To search for adverse reactions of ADR injections admitted to Chinese Academic Journal Full-text Database (CNKI) and VIP Chinese Science and Technology Periodical Database (VIP) since 2006, and to register in the National ADR Reports Center for Disease Control and Prevention Reaction information, statistical analysis. Results: A total of 653 cases of adverse reactions were reported in the literature. The age distribution ranged from 0 to 17 years old (398 cases, 61%) and occurred within 30 minutes (510 cases, 78%). The number of organs and systems were more common, with skin and its accessory lesions and generalized lesions being more common (358 cases, 51%). The majority of adverse reactions were cured and improved (605 cases, 92.6%). No cases of death were found. Conclusions: At the same time, Yanhu Ning should be used clinically and appropriately to monitor the medication to reduce the incidence of adverse reactions.