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目的:探讨改善微循环对周围神经嵌压性损害血管内皮细胞生长因子(VEGF)表达和病理改变的影响。方法:分别检测坐骨神经嵌压后12、72h和7d背根神经节细胞VEGF水平与第4周神经干、神经节病理变化、脊髓病变神经元计数等,并运用正常对照组、模型组、前列地尔组和丁咯地尔组采用SPSS10.0统计软件进行方差分析统计处理。结果:嵌压后72hVEGF水平达到高峰,与正常对照组比较,其余各组均显著增加(P<0.01,P<0.05);前列地尔组和丁咯地尔组较模型组为优(P<0.01,P<0.05);嵌压后4周前列地尔组和丁咯地尔组的神经干、神经节病理变化、脊髓病变神经元计数均优于模型组(P<0.05)。结论:对于周围神经嵌压性损害,改善微循环可增加VEGF的表达并减轻其病理损害,从而对周围神经嵌压性损害的修复具有促进作用。
Objective: To investigate the effect of microcirculation on vascular endothelial growth factor (VEGF) expression and pathological changes induced by entrapment injury in peripheral nerves. Methods: The levels of VEGF in DRG neurons at 12, 72h and 7d after sciatic nerve impaction were compared with those in the 4th week, the pathological changes of neural stem cells, ganglion neurons and spinal cord neurons. The normal control group, model group, Erdeng group and buflomedil group using SPSS10.0 statistical software analysis of variance statistical processing. Results: The level of VEGF reached a peak at 72 hours after embedding, and the other groups were significantly increased compared with the normal control group (P <0.01, P <0.05); the alprostadil group and buflomedil group were superior to the model group (P < 0.01, P <0.05). The neural stem cells, ganglion pathological changes and myelinated neurons in the alprostadil group and the buflomedil group were better than those in the model group (P <0.05). CONCLUSIONS: With respect to the peripheral nerve entrapment injury, improving microcirculation can increase the expression of VEGF and alleviate the pathological damage, which can promote the repair of the peripheral nerve entrapment injury.