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目的 探讨钙黏蛋白 链蛋白 (Cadherin catenin)复合体在进展期胃癌转移淋巴结的再表达及其临床意义。方法 用免疫组织化学染色的方法检测并比较上皮钙黏蛋白 (E cadherin) ,α 和 β 链蛋白 (catenin)在 96例胃癌原发灶与 79例转移淋巴结内的表达 ,并结合临床病理资料与随访结果进行综合分析。结果 79例转移淋巴结中 5 2例 (66%)出现了一个或多个蛋白分子的再表达 ,并与肿瘤的临床病理分期密切相关 ;再表达阳性组和阴性组的 5年生存率分别是 8%和 3 3 %,两者差异有显著性 (P <0 .0 1)。结论 钙黏蛋白 链蛋白复合体在进展期胃癌转移淋巴结的再表达对癌细胞在转移灶的聚集生长起着重要作用 ,可作为胃癌预后的一个新指标。
Objective To investigate the re-expression of cadherin catenin complex in metastatic lymph nodes of advanced gastric cancer and its clinical significance. Methods The expressions of E cadherin, α and β catenin in 96 cases of primary gastric cancer and 79 cases of metastatic lymph nodes were detected by immunohistochemical staining and compared with clinicopathological data Follow-up results for a comprehensive analysis. Results The re-expression of one or more protein molecules occurred in 52 cases (66%) of 79 metastatic lymph nodes and was closely related to the clinicopathological stage of the tumor. The 5-year survival rates of the re-expression positive group and negative group were 8 % And 33% respectively, the difference was significant (P <0.01). Conclusions The re-expression of cadherin-linked protein complex in metastatic lymph nodes of advanced gastric cancer plays an important role in the accumulation and growth of cancer cells in metastatic lymph nodes, which may serve as a new indicator of the prognosis of gastric cancer.